Paola A. Marignani

About

Work

Dalhousie University
|

PI

Canada

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Education

Dalhousie University
Canada

→

Micro Credential Indigenous Teaching and Learning

Massachusetts Institute of Technology
United States of America

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Artificial Intelligence in Health Care

McMaster University
Canada

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PhD

Publications

The Tumor Suppressor Kinase LKB1: Metabolic Nexus

Published by

Frontiers in Cell and Developmental Biology

Summary

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Single-Cell RNA Sequencing Analysis Using Fluidigm C1 Platform for Characterization of Heterogeneous Transcriptomes.

Published by

Methods in molecular biology (Clifton, N.J.)

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Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood

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npj Genomic Medicine

Summary

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Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

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Cancers

Summary

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Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

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Cancers

Summary

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Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

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Cancers

Summary

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Profiling non-small cell lung cancer reveals that PD-L1 is associated with wild type EGFR and vascular invasion, and immunohistochemistry quantification of PD-L1 correlates weakly with RT-qPCR

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PLOS ONE

Summary

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S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis

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Cancers

Summary

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S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis

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Cancers

Summary

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Molecular profiling of non-small cell lung cancer

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PLoS ONE

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Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells.

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American journal of cancer research

Summary

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MA24.11 Loss of Tumour Suppressors is Adequate and Sufficient to Drive Lung Cancer in CRISPR/Cas9 Mice

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Journal of Thoracic Oncology

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Ranitidine inhibition of breast tumor growth is B cell dependent and associated with an enhanced antitumor antibody response

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Frontiers in Immunology

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Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)<sup>☆</sup>

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Cell Death and Disease

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Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

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Oncogene

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Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice

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OncoImmunology

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Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead

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Carcinogenesis

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Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

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Carcinogenesis

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Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss

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Oncotarget

Summary

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Correction: Loss of lkb1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways (PLoS ONE)

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PLoS ONE

Summary

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Loss of lkb1 Expression Reduces the Latency of ErbB2-Mediated Mammary Gland Tumorigenesis, Promoting Changes in Metabolic Pathways

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PLoS ONE

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Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1

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Cancer Biology and Therapy

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LKB1 catalytic activity contributes to estrogen receptor α signaling

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Molecular Biology of the Cell

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Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells

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Cancer Biology and Therapy

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Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2

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American Journal of Physiology - Cell Physiology

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LKB1 catalytically deficient mutants enhance cyclin D1 expression

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Cancer Research

Summary

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Novel splice isoforms of STRADα differentially affect LKB1 activity, complex assembly and subcellular localization

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Cancer Biology and Therapy

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LKB1, the multitasking tumour suppressor kinase

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Journal of Clinical Pathology

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Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

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Molecular and Cellular Biology

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LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest

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Journal of Biological Chemistry

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Target gene therapy for α-fetoprotein-producing hepatocellular carcinoma by E1B55k-attenuated adenovirus

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Biochemical and Biophysical Research Communications

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Vav2 is required for cell spreading

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Journal of Cell Biology

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TAZ: a novel transcriptional co‐activator regulated by interactions with 14‐3‐3 and PDZ domain proteins

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The EMBO Journal

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TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

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EMBO Journal

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Association of protein kinase Cμ with type II phosphatidylinositol 4- kinase and type I phosphatidylinositol-4-phosphate 5-kinase

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Journal of Biological Chemistry

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Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) acids

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Advances in Experimental Medicine and Biology

Summary

book

Acyl chain dependence of diacylglycerol activation of protein kinase C activity in vitro

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Biochemical and Biophysical Research Communications

Summary

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Erratum: Formation of second messenger diradylglycerol in murine peritoneal macrophages is altered after in vivo (n-3)polyunsaturated fatty acid supplementation (Journal of Nutrition (1995) 125 (3030-3040))

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Journal of Nutrition

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Formation of sk-1,2-diradyl glycerol following eicosapentaenoic and docosahexaenoic ethyl ester supplementation w vivo

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FASEB Journal

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The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters

Published by

Journal of Nutrition

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n-3 Polyunsaturated fatty acid-induced changes in the molecular species composition of diradylglycerol in murine peritoneal macrophages remain stable during incubation ex vivo

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Lipids

Summary

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Formation of second messenger diradylglycerol in murine peritoneal macrophages is altered after in vivo (n-3) polyunsaturated fatty acid supplementation

Published by

Journal of Nutrition

Summary

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